Background: Major adverse cardiovascular events are the main cause of morbidity and mortality over the long\nterm in patients undergoing carotid endarterectomy. There are few reports assessing the prognostic value of\nmarkers of inflammation in relation to the risk of cardiovascular disease after carotid endarterectomy. Here, we\naimed to determine whether matrix metalloproteinases (MMP-1, MMP-2, MMP-7, MMP-9 and MMP-10), tissue\ninhibitor of MMPs (TIMP-1) and in vivo inflammation studied by 18F-FDG-PET/CT predict recurrent cardiovascular\nevents in patients with carotid stenosis who underwent endarterectomy.\nMethods: This prospective cohort study was carried out on 31 consecutive patients with symptomatic (23/31) or\nasymptomatic (8/31) severe (> 70%) carotid stenosis who were scheduled for carotid endarterectomy between July\n2013 and March 2016. In addition, 26 healthy controls were included in the study. Plasma and serum samples were\ncollected 2 days prior to surgery and tested for MMP-1, MMP-2, MMP-7, MMP-9, MMP-10, TIMP-1, high-density\nlipoprotein, low-density lipoprotein, high-sensitivity C-reactive protein and erythrocyte sedimentation rate. 18F-FDGPET/\nCT focusing on several territoriesâ?? vascular wall metabolism was performed on 29 of the patients because of no\npresurgical availability in 2 symptomatic patients. Histological and immunohistochemical studies were performed\nwith antibodies targeting MMP-10, MMP-9, TIMP-1 and CD68.
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